This document provides an overview of advanced econometrics techniques including simulations, bootstrap methods, and penalization. It discusses how computers allow for numerical standard errors and testing procedures through simulations and resampling rather than relying on asymptotic formulas. Specific techniques covered include the linear regression model, nonlinear transformations, asymptotics versus finite samples using bootstrap, and moving from least squares to other regressions like quantile regression. Historical references for techniques like permutation methods, the jackknife, and bootstrapping are also provided.