The popliteal fossa is a diamond-shaped area behind the knee, bounded by muscles including semimembranosus and biceps femoris, with compartments for various nerves and blood vessels. It contains the sciatic nerve, popliteal artery, and vein, which give rise to terminal branches and interact with surrounding structures. The roof of the fossa is formed by the popliteal fascia, and several muscles such as the gastrocnemius, semitendinosus, and biceps femoris are detailed in terms of origin, insertion, action, nerve supply, and blood supply.