Third Ventricle’s Chordoid Gliomas_Crimson Publishers
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This mini review discusses chordoid gliomas located in the third ventricle, highlighting their histological characteristics, typical patient demographics, and clinical symptoms primarily related to obstructive hydrocephalus. The article emphasizes the importance of distinguishing these tumors from similar conditions like chordoid meningiomas and chordomas based on immunohistochemical profiles. Complete surgical resection is identified as the most effective treatment, with incomplete resection potentially leading to a poorer prognosis.
![Third Ventricle’s Chordoid Gliomas
Behzad Saberi*
Medical Research, Iran
Crimson Publishers
Wings to the Research
Mini Review
*Corresponding author: Behzad Saberi,
Medical Research, Esfahan, Iran
Submission: December 04, 2019
Published: Janauary 13, 2020
Volume 4 - Issue 1
How to cite this article: Behzad S. Third
Ventricle’s Chordoid Gliomas. Nov Appro
in Can Study. 4(1). NACS.000579.2020.
DOI: 10.31031/NACS.2020.04.000579
Copyright@ Behzad Saberi, This article is
distributed under the terms of the Creative
Commons Attribution 4.0 International
License, which permits unrestricted use
and redistribution provided that the
original author and source are credited.
ISSN: 2637-773X
331
Novel Approaches in Cancer Study
Mini Review
This is a brief review on the Third Ventricle’s Chordoid Gliomas and their pathogenesis.
Chordoid gliomas of the third ventricle are histologically characterized by chordoma-like
features. These rare tumors can be seen mostly in the adult patients group specifically in
the women population. These solid tumors are well-circumscribed which are adhered to
the wall of the third ventricle [1]. Their location is in the anterior part of the third ventricle.
These glioma tumors may be extended to reach the suprasellar region. Also, they may cause
a hydrocephalus which is obstructive in nature. Regarding differential diagnosis for chordoid
glioma, chordoid meningioma and chordoma should be of notice [2].
Chordomas contain physaliphorous cells. They also stain positive for cytokeratins. CD34
andlackofimmunoreactivityforGlialfibrillaryacidicprotein,canalsobeseeninthesetumors.
These findings differentiate chordomas from gliomas [3]. Chordoid meningiomas show some
meningeal features like psammoma bodies and whorl formation. Also, cordoid meningiomas
are negative for CD34 and Glial fibrillary acidic protein and positive for Epithelial membrane
antigen [4]. These characteristics differentiate chordoid meningiomas from chordoid gliomas.
Chordoid gliomas are different from common glioma and meningioma types. They do not
have chromosal imbalances. Also, there are not any CDK4, TP53, EGFR, MDM2 and CDKN2A
genetic alterations in chordoid gliomas [5].
Positivity for vimentin, CD34 and Glial fibrillary acidic protein can also be seen in the
chordoid glioma tumors. Different expressions of cytokeratines, S-100 and Epithelial
membrane antigen can be seen in chordoid gliomas. Lack of P53 nuclear accumulation can
be seen in such tumors either. The MIB1 index is less than five percent and the synaptophysin
is negative in the immunohistochemical profile of the chordoid gliomas [6]. The lympho-
plasmacellular infiltrations, are regular features of chordoid gliomas. There is no sign of
anaplasia and there is a low amount of mitotic activity in such tumors. Reactive astrogliosis
usually with Rosenthal fibers can be seen in these tumors which are demarcated from the
brain tissue around them [7].
References
1. Tonami H, Kamehiro M, Oguchi M, Higashi K, Yamamoto I, et al. (2000) Chordoid glioma of the third
ventricle: CT and MR findings. J Comput Assist Tomogr 24(2): 336-338.
2. Desouza RM, Bodi I, Thomas N, Marsh H, Crocker M (2010) Chordoid glioma: Ten years of a low-grade
tumor with high morbidity. Skull Base 20(2):125-138.
3. Ni HC, Piao YS, Lu DH, Fu YJ, Ma XL, et al. (2013) Chordoid glioma of the third ventricle: Four cases
including one case with papillary features. Neuropathology 33(2):134-139.
4. Jung TY, Jung S (2006) Third ventricular chordoid glioma with unusual aggressive behavior. Neurol
Med Chir (Tokyo) 46(12): 605-608.
Abstract
Chordoid gliomas are low grade tumors which are most commonly seen in women and in the adult popu-
lation. Clinical signs and symptoms of these tumors are mostly related to hydrocephalus which is obstruc-
tive in nature. Headache, nausea, visual disturbances, imbalances in the endocrine system and autonomic
dysfunction can be seen in these tumors. MRI with contrast is the best diagnostic imaging method for
such tumors. The best treatment method for such tumors would be complete surgical resection. In case
of incomplete resection, the prognosis can be poorer in comparison with complete surgical resection.](https://image.slidesharecdn.com/nacs-210710055037/85/Third-Ventricle-s-Chordoid-Gliomas_Crimson-Publishers-1-320.jpg)
Third Ventricle’s Chordoid Gliomas_Crimson Publishers
- 1. Third Ventricle’s Chordoid Gliomas Behzad Saberi* Medical Research, Iran Crimson Publishers Wings to the Research Mini Review *Corresponding author: Behzad Saberi, Medical Research, Esfahan, Iran Submission: December 04, 2019 Published: Janauary 13, 2020 Volume 4 - Issue 1 How to cite this article: Behzad S. Third Ventricle’s Chordoid Gliomas. Nov Appro in Can Study. 4(1). NACS.000579.2020. DOI: 10.31031/NACS.2020.04.000579 Copyright@ Behzad Saberi, This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use and redistribution provided that the original author and source are credited. ISSN: 2637-773X 331 Novel Approaches in Cancer Study Mini Review This is a brief review on the Third Ventricle’s Chordoid Gliomas and their pathogenesis. Chordoid gliomas of the third ventricle are histologically characterized by chordoma-like features. These rare tumors can be seen mostly in the adult patients group specifically in the women population. These solid tumors are well-circumscribed which are adhered to the wall of the third ventricle [1]. Their location is in the anterior part of the third ventricle. These glioma tumors may be extended to reach the suprasellar region. Also, they may cause a hydrocephalus which is obstructive in nature. Regarding differential diagnosis for chordoid glioma, chordoid meningioma and chordoma should be of notice [2]. Chordomas contain physaliphorous cells. They also stain positive for cytokeratins. CD34 andlackofimmunoreactivityforGlialfibrillaryacidicprotein,canalsobeseeninthesetumors. These findings differentiate chordomas from gliomas [3]. Chordoid meningiomas show some meningeal features like psammoma bodies and whorl formation. Also, cordoid meningiomas are negative for CD34 and Glial fibrillary acidic protein and positive for Epithelial membrane antigen [4]. These characteristics differentiate chordoid meningiomas from chordoid gliomas. Chordoid gliomas are different from common glioma and meningioma types. They do not have chromosal imbalances. Also, there are not any CDK4, TP53, EGFR, MDM2 and CDKN2A genetic alterations in chordoid gliomas [5]. Positivity for vimentin, CD34 and Glial fibrillary acidic protein can also be seen in the chordoid glioma tumors. Different expressions of cytokeratines, S-100 and Epithelial membrane antigen can be seen in chordoid gliomas. Lack of P53 nuclear accumulation can be seen in such tumors either. The MIB1 index is less than five percent and the synaptophysin is negative in the immunohistochemical profile of the chordoid gliomas [6]. The lympho- plasmacellular infiltrations, are regular features of chordoid gliomas. There is no sign of anaplasia and there is a low amount of mitotic activity in such tumors. Reactive astrogliosis usually with Rosenthal fibers can be seen in these tumors which are demarcated from the brain tissue around them [7]. References 1. Tonami H, Kamehiro M, Oguchi M, Higashi K, Yamamoto I, et al. (2000) Chordoid glioma of the third ventricle: CT and MR findings. J Comput Assist Tomogr 24(2): 336-338. 2. Desouza RM, Bodi I, Thomas N, Marsh H, Crocker M (2010) Chordoid glioma: Ten years of a low-grade tumor with high morbidity. Skull Base 20(2):125-138. 3. Ni HC, Piao YS, Lu DH, Fu YJ, Ma XL, et al. (2013) Chordoid glioma of the third ventricle: Four cases including one case with papillary features. Neuropathology 33(2):134-139. 4. Jung TY, Jung S (2006) Third ventricular chordoid glioma with unusual aggressive behavior. Neurol Med Chir (Tokyo) 46(12): 605-608. Abstract Chordoid gliomas are low grade tumors which are most commonly seen in women and in the adult popu- lation. Clinical signs and symptoms of these tumors are mostly related to hydrocephalus which is obstruc- tive in nature. Headache, nausea, visual disturbances, imbalances in the endocrine system and autonomic dysfunction can be seen in these tumors. MRI with contrast is the best diagnostic imaging method for such tumors. The best treatment method for such tumors would be complete surgical resection. In case of incomplete resection, the prognosis can be poorer in comparison with complete surgical resection.
- 2. 332 Nov Appro in Can Study Copyright © Behzad Saberi NACS.000579. 4(1).2020 5. Nakajima M, Nakasu S, Hatsuda N, Takeichi Y, Watanabe K, et al. (2003) Third ventricular chordoid glioma: Case report and review of the literature. Surg Neurol 59(5): 424-428. 6. Brat DJ, Scheithauer BW, Staugaitis SM, Cortez SC, Brecher K, et al. (1998) Third ventricular chordoid glioma: A distinct clinicopathologic entity. J Neuropathol Exp Neurol 57(3): 283-290. 7. Kobayashi T, Tsugawa T, Hashizume C, Arita N, Hatano H, et al. (2013) Therapeutic approach to chordoid glioma of the third ventricle. Neurol Med Chir (Tokyo) 53(4): 249-255. For possible submissions Click below: Submit Article