This document discusses ONE Automation, an approach from UC4 that integrates and orchestrates workflows across an entire enterprise using a single automated process stream. It addresses the problem of technology silos created by virtualization and cloud computing. The UC4 Automation Platform is presented as the solution, allowing end-to-end monitoring, orchestration, and execution across physical, virtual and cloud environments. It combines process automation with complex event processing to make automated decisions based on business indicators across the entire organization.