Adam Fabriwerk Processing Skids Presentation Sterile Processing
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Adam Fabriwerk is an Indian company that has been delivering mixing and processing machinery to the biopharmaceutical, pharmaceutical, and cosmetic industries for 26 years. It has offices in Mumbai and a manufacturing facility in Nashik staffed by 150 people. The document provides details about Adam Fabriwerk's board of directors, manufacturing site capabilities including fabrication, testing, and a new sterile facility, product profile including blending vessels and automation systems, projects for clients in India and other countries, and international presence exhibiting at various trade shows.
Adam Fabriwerk Processing Skids Presentation Sterile Processing
- 1. Vishal Wagh Director Marketing www.adamfabriwerk.com 1
- 2. Summary Indian Ethos Company Overview Manufacturing Site Product Profile Projects International Presence www.adamfabriwerk.com 2
- 3. Summary Indian Ethos Company Overview Manufacturing Site Product Profile Projects International Presence www.adamfabriwerk.com 3
- 4. Company Overview Adam Fabriwerk has been Mumbai To Nashik delivering quality mixing and processing machinery products to Biopharmaceutical, Pharmaceutical and Cosmetic Industries for the past 26 years Our corporate offices are based in Mumbai, India and our Manufacturing Facilities and R&D labs are located at Nashik,160 kms away from Mumbai Nashik Works Strength : 150 people www.adamfabriwerk.com 4
- 5. Company Overview :Board of Directors Waman Wagh Technical Director Devidas Shirude Finance Director Sanjay Shirude Production Director Vishal Wagh Marketing Director www.adamfabriwerk.com 5
- 6. Summary Indian Ethos Company Overview Manufacturing Site Product Profile Projects International Presence www.adamfabriwerk.com 6
- 7. Manufacturing Site Fabrication Facility In house Design,Manufacturing,FAT facilities Orbital Welding machines with Boroscopy for Tubes Overhead Cranes covering Complete Factory Bay areas for Material Handling Total Fabrication area availability 1800 Sq.Metres Maximum Capacity of Vessel fabrication 30000 Litres Polishing Bays separate from Fabrication and Assembly areas Vessel Design as per ASME BPE- 2005 and ASME Sec VIII Div 1 Qualified Welders as per ASME Sec IX www.adamfabriwerk.com 7
- 8. Manufacturing Site Display Facility Operator Training Modules Prospective Clients get a first hand look at the end product Ease of finalising specific process critical accessories and fitments Mixing/Blending Vessels,CIP,SIP Modules and Cream Mixers on Display with Full Process Control Options with Production Scale Models All World Class Bought outs used in Integration of the Skids on Display www.adamfabriwerk.com 8
- 9. Manufacturing Site FAT Area Vessel Hydro Tests Jacket Hydro Tests Vessel/Jacket Vacuum Tests Mixing Water Trials Full BOQ/MOC Documentation Dossiers including DQ/IQ/OQ/PLC Validation Packages available Full Operational Tests performed under FAT Welding Maps with X ray Reports Surface Finish Test with Profilometer Electropolishing Reports Riboflavin Tests for Sprayball Efficacy www.adamfabriwerk.com 9
- 10. Manufacturing Site New State-of-the-Art Facility This new facility is designed for the fabrication of 100 percent stainless steel projects. Unit 2 The plant will boast of a controlled environment ensuring high purity and cross contamination prevention to comply with regulatory standards. It will also incorporate automated welding processes and advanced finishing processes as well as a designated area for factory acceptance testing. With a height of 31 feet under hook and a 50 ton lift capacity, it is ideal for large or small tanks as well as super skids. www.adamfabriwerk.com 10
- 11. Summary Indian Ethos Company Overview Manufacturing Site Product Profile Projects International Presence www.adamfabriwerk.com 11
- 12. Product Profile : Blending Vessels Mixing Applications Bacteria and Cell Cultures Suspensions Blood fractions in Cohn fractionation Vaccine suspensions containing aluminium hydrogel, salts, antibodies Dissolving glucose in water (LVP solutions) Capacity 5 to 30000 Litres www.adamfabriwerk.com 12
- 13. Product Profile : Blending Vessels Sterile Sampling System with In Situ Steam Sterilization Sterile Flange Connections for Top dish nozzles to enhance CIP,SIP operations Temperature/pH/Conductivity sensing through sanitary knuckle port on vessel shell Load Cells for weight measurement Vessel with CIP / SIP able accessories PLC system with SCADA available for batch records www.adamfabriwerk.com 13
- 14. Product Profile : Blending Vessels GMP Mixer General Mixing The GMP mixer is suitable for general Mixing,Blending,Heat transfer and Shear Sensitive Applications Speed variation from 20 to 350 RPM Upstream processing The USM mixer is a superior alternative to USM Mixer top-mounted mixers in upstream mixing applications The USM mixer creates medium high- shear forces and transfers much more energy into the tank than the GMP mixer, and is ideal for mixing difficult powders into a liquid Speed variation from 300 to 1440 RPM www.adamfabriwerk.com 14
- 15. Product Profile : Blending Vessels HS Mixer Rotor High Shear Mixing Applications Homogenizing-Dispersing activities Stator Suspension of Solid Particles in Liquid Phase Dissolving and Downsizing Particles for Suspension Manufacturing Emulsification to achieve small Droplet Size to achieve Stable Emulsions Tank Plate Speed variation from 400 to 2800 RPM Combo Mixing High Shear Combo Mixing A HS mixer creates the High Shear Forces needed to create an Emulsion, while the GMP mixer is used to break the vortex and create additional Drive agitation and balance in the tank A variety of powerful results can be achieved this way, such as controlling vortex to prevent foaming, increased agitation, etc. www.adamfabriwerk.com 15
- 16. Product Profile : Blending Vessels Take Off Tank Outlet Valve Configurations Take Off Valves Used in PW and WFI Loops, free of Dead Legs and No Pressure Drop over the valve in the main line Tank Outlet Valves Truly Zero Dead Leg with Multiple ports and Actuation options Shut Off Flow Through Shut Off Valves Positive Sealing with no cavities, Full Drainability and Low Pressure Drop Flow Through Valves Manifold, Take Off and Drainage Valves in Aseptic Applications www.adamfabriwerk.com 16
- 17. Product Profile : Blending Vessels LVP Project Profiling Photo Courtesy:Charak Pharmaceuticals www.adamfabriwerk.com 17
- 18. Product Profile : Blending Vessels LVP Project Profiling www.adamfabriwerk.com 18
- 19. Product Profile : Blending Vessels LVP Preparation tanks Jacketed/Insulated/Cladded Vessel Bottom Entry Propeller Mixer for vigorous MASS MOVEMENT within the vessel Bottom Entry Magnetic mixer mounted within the vessel Lug Mounted Vessel on Platform with Load cells Mixing of 10000 litres of water www.adamfabriwerk.com 19
- 20. Product Profile : Blending Vessels Transfer Panels Panel Design Jumper Design Jumper Holders Port Caps Drain Pan Proximity Switches Photo Courtesy: Johnson & Johnson Panel Support Panel and Port Labeling www.adamfabriwerk.com 20
- 21. Product Profile : CIP System Applications : Cleaning In Place of Cream Manufacturing Vessel Intermediate Preparation Vessels Storage Vessels Product Transfer lines Photo Courtesy: Encube Ethicals www.adamfabriwerk.com 21
- 22. Product Profile : CIP System Completely Automated Process Cycles of Pre Wash/Air blow/Detergent Wash/Rinse /Drying On line display of process parameters with P & I of Operating System Real Time Recording and Print /Communication of Process Parameters Detergent / Acid / Alkali Automated Dosing system On Line pH,Conductivity, TOC Sensing CIP is designed in accordance with ASME BPE guidelines PLC-based, with Touch Screen MMI and SCADA Packages www.adamfabriwerk.com 22
- 23. Product Profile : CIP System Key Benefits of CIP Process Validatable process for cleaning of process equipment Lower facility operating costs Minimal dismantling of Cleaning In Place Cycle equipment and piping Reduced turnaround time for cleaning WFI requirements for cleaning reduced significantly Exposure to hazardous activities or entry into tanks, is eliminated www.adamfabriwerk.com 23
- 24. Product Profile : CIP System Key Benefits of CIP Process Validatable process for cleaning of process equipment Lower facility operating costs Minimal dismantling of equipment and piping Reduced turnaround time for cleaning WFI requirements for cleaning reduced significantly Exposure to hazardous activities or entry into tanks, is eliminated www.adamfabriwerk.com 24
- 25. Product Profile : CIP System Flow Characteristics and Measurement Sanitary Flow meter www.adamfabriwerk.com 25
- 26. Product Profile : CIP System PID Of Plant wide CIP System www.adamfabriwerk.com 26
- 27. Automation HMI Screens : Manufacturing Vessel www.adamfabriwerk.com 27
- 28. Automation HMI Screens : Phase Preparation Vessel www.adamfabriwerk.com 28
- 29. Automation HMI Screens : Product Preparation Steps www.adamfabriwerk.com 29
- 30. Automation HMI Screens : CIP System www.adamfabriwerk.com 30
- 31. Automation HMI Screens : CIP System Steps www.adamfabriwerk.com 31
- 32. Summary Indian Ethos Company Overview Manufacturing Site Product Profile Projects International Presence Trade Shows www.adamfabriwerk.com 32
- 33. Sterile Processing Projects www.adamfabriwerk.com 33
- 34. Sterile Processing Projects www.adamfabriwerk.com 34
- 35. Sterile Processing Projects www.adamfabriwerk.com 35
- 36. Projects Reliance Lifesciences Sanofi Aventis India Egypt Blood Plasma Products Semi Solids Processing Plant www.adamfabriwerk.com 36
- 37. Projects Serum Institute Of India EIMC India Egypt DSP Area Blending Vessels for Vaccine Formulation Vessels HIB Vaccine Project www.adamfabriwerk.com 37
- 38. Projects Johnson & Johnson Encube Ethicals India India Fully Integrated SCADA Controlled Semi Solids-Liquids Fully Automated Semi Solid/Emulsions Facility Processing Facility www.adamfabriwerk.com 38
- 39. Summary Indian Ethos Company Overview Manufacturing Site Product Profile Projects International Presence www.adamfabriwerk.com 39
- 40. International Presence Interphex Singapore 2005 CPHI India 2006 Interphex New York 2007 Interphex India 2007 Interphex Philadelphia 2008 Interphex Canada 2008 www.adamfabriwerk.com 40