This document discusses a new enhanced method for nonparametric power spectrum estimation called iterative adaptive approach (IAA), which is designed to improve spectral analysis of non-uniformly sampled data sequences. It compares existing methods such as the Fourier periodogram, least squares periodogram (LSP), Welch, MUSIC, and ESPRIT, highlighting the limitations of traditional methods and demonstrating the advantages of IAA in terms of accuracy and computational efficiency. Additionally, it presents a framework for designing optimal sampling patterns based on prior spectral estimates to minimize errors in future measurements.