The document discusses the current progress on the design and analysis of bonded metal-composite joints for the James Webb Space Telescope (JWST) Integrated Science Instrument Module (ISIM) that must survive at cryogenic temperatures of 22K. Key challenges include large thermal stresses due to CTE mismatches at cryogenic temperatures and lack of test data on material properties and strengths at temperatures below 80K. Several basic joint designs (plug, saddle, T-joint) are being analyzed using finite element models to evaluate stresses and calculate safety factors with a goal of survival through launch loads and multiple thermal cycles. Test data is being used to develop failure criteria curves and validate the analysis. Margins of safety above 1 have been achieved for critical failure