This document provides an overview of locomotion and support systems in the human body. It discusses the diversity of skeletons including hydrostatic, exoskeletons, and endoskeletons. It then focuses on the human skeletal and muscular systems. The skeletal system is divided into the axial skeleton (skull, vertebral column, ribs, sternum) and appendicular skeleton (shoulder, pelvis, limbs). Muscles contract via a sliding filament model which causes sarcomeres to shorten and the muscle to contract. Nerve signals trigger calcium release and the cross-bridging of actin and myosin fibers.