This document discusses methods for making inferences about two independent population means based on sample data. It presents three methods: (1) when the two population standard deviations are unknown and not assumed to be equal, (2) when the two population standard deviations are both known, and (3) when the two population standard deviations are unknown but assumed to be equal. It recommends using the first method which uses a t-test and does not assume the standard deviations are equal, as this approach is most realistic. Examples are provided to illustrate hypothesis testing and constructing confidence intervals for the difference between two means.