Chlorobutanol
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Chlorobutanol is a colorless to white crystalline compound with a camphoraceous odor and taste. It is widely used as a preservative in pharmaceutical solutions, especially injectables, and is an active ingredient in certain oral sedatives and topical anesthetics. Chlorobutanol is prepared by reacting chloroform and acetone in the presence of a strong base such as potassium hydroxide. It is used as a preservative in pharmaceutical preparations to protect them from chemical change or microbial action.
Chlorobutanol
- 1. CHLOROBUTANOL - COMPOUND Also known as: Chlorbutol, CHLORETONE, Acetonchloroform, Acetochlorone, Chlorbutanol, Coliquifilm, Chloreton, Chlortran, Clortran Molecular Formula: C4H7Cl3O Molecular Weight: 177.45678 InChIKey: OSASVXMJTNO KOY-UHFFFAOYSA-N A colorless to white crystalline compound with a camphoraceous odor and taste. It is a widely used preservative in various pharmaceutical solutions, especially injectables. Also, it is an active ingredient in certain oral sedatives and topical anesthetics. From: MeSH
- 2. SHOW SUBCONTENT TITLESTABLE OF CONTENTS Identification Related Records Use and Manufacturing Pharmacology Biomedical Effects and Toxicity Safety and Handling Exposure Standards and Regulations Monitoring and Analysis Methods Literature Patents Biological Test Results Classification Chemical and Physical Properties
- 3. 2D STRUCTURE
- 5. RELATED COMPOUNDS WITH ANNOTATION hexylene glycol 1,1,1-trifluoro- -2-propan... BM 567 hexafluoroisopropanol 3-hydroxy-3-met- hylbutene
- 6. USE AND MANUFACTURING Prepn: prepd by action of powdered potassium hydroxide or of potassium ethoxide solution on mixture of chloroform & acetone . By action of potassium hydroxide on a solution of chloroform and acetone. The para and ortho positions of phenols condense at the carbonyl group of acetone to make bisphenols... If the H atom is activated, ClCH- compounds add to the carbonyl group in the presence of stong base; chloroform gives chloretone.
- 7. PHARMACOLOGY Preservatives, Pharmaceutical - Substances added to pharmaceutical preparations to protect them from chemical change or microbial action. They include ANTI-BACTERIAL AGENTS and antioxidants. (Pharmacological Action, Therapeutic Uses, Drug Warning, Drug Idiosyncracies, Minimum/Potential Fatal Human Dose)
- 8. BIOMEDICAL EFFECTS AND TOXICITY SOLN CONTAINING...0.4% CHLOROBUTANOL...UNDER CONTACT LENS...LEFT ON EYE FOR SEVERAL MIN...UNCOMFORTABLE KERATITIS EPITHELIALIS HAS RESULTED, WITH FOGGING OF VISION, HALOES AROUND LIGHTS, & FOREIGN-BODY TYPE OF DISCOMFORT BEGINNING WITHIN HR & BECOMING WORSE...EYES HAVE RECOVERED SPONTANEOUSLY & COMPLETELY IN DAY OR TWO. This substance may be habit forming
- 9. EXPOSURE STANDARDS AND REGULATIONS FDA Requirements Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392). Chloretone is a chemical derivative of chloral, named in section 502(d) of the Federal Food, Drug, and Cosmetic Act and is hereby designated as habit forming.
- 10. MONITORING AND ANALYSIS METHODS Analytic Laboratory Methods AOAC Method 936.17. Chlorinated hydrocarbons in drugs. Infrared Spectrophotometric Method. /Chlorinated hydrocarbons AOAC Method 967.29. Chlorobutanol in drugs. Gas chromatographic and infrared methods. /Chlorobutanol
- 11. COMPUTED PROPERTIES EP1032403 5-3-2012 NUTRITIONAL SUPPLEMENT FOR CEREBRAL METABOLIC INSUFFICIENCIES EP0894143 4-19-2012 VMP-LIKE SEQUENCES OF PATHOGENIC BORRELIA VMP-LIKE SEQUENCES OF PATHOGENIC BORRELIA EP0845977 12-22-2011 CLEAR COSMETIC GEL COMPOSITION CLEAR COSMETIC GEL COMPOSITION
- 12. CHEMICAL AND PHYSICAL PROPERTIES NEEDLES (WATER+1) Crystals COLORLESS TO WHITE Colorless to white crystals Odor Camphor odor Characteristic odor Taste Camphor taste Characteristic taste
- 13. SOLUBILITIES HOT WATER INSOL IN COLD WATER, SOL IN 1 G IN 125 ML WATER; SOL IN VOLATILE OILS Easily sol in hot water; one gram dissolves in 1 ml alcohol, 10 ml glycerol; sol in chloroform, ether, acetone, petr ether, glacial acetic acid, oils. Soluble in alcohol and glycerol, hot water, ether, chloroform, and volatile oils. Soluble in ethanol, ethyl ether, and acetone. In water, 8,000 mg/l @ 20 deg C