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Project Update
BOSC 2011
Scott Cain
GMOD Project Coordinator
Ontario Institute for Cancer Research
scott@scottcain.net
What Is GMOD?

• A set of interoperable open-source software
  components for  visualizing, annotating, and
  managing biological data.

• An active  community of developers and
  users asking diverse questions, and facing
  common challenges, with their biological data.
G07-Misc-Gmod
What's New

• Chado Natural Diversity Module

• Tripal

• GBrowse2

• GMOD in the Cloud
Natural Diversity Chado Module
Generic, Flexible Schema
Use case: insecticide resistance assay
Use case: mosquito field collection
Use case: rice growth condition
Tripal: a construction toolkit for online
              biological databases
Relational Database                Web Content Management
                                     • Drupal
GMOD Chado                              • Requires little or no
                                          programming
Community supported                     • Users can change
                                          content directly
Well documented                         • Well documented and
                                          supported
Integrates with a suite of tools        • Very Popular
Tripal: a construction toolkit for online
                biological databases
• Benefits
  –   Reduced IT costs (less programming)
  –   Faster time to release
  –   Active development (released v0.3b in June)
  –   Support: Mailing list, online tutorials, responsive developers
  –   Already used by multiple genome databases

  – Use of Chado allows for use of other GMOD tools
      • Maker: automatic genome curation
      • Apollo: manual curation
      • GBrowse: genome visualization

  – Use of Drupal allows for incorporation of non-biological content
      • Forums, RSS feeds, community pages,
      • Site stake-holders can add / update content without waiting on programmers
Tripal: a construction toolkit for online
          biological databases
Tripal: what’s new?

• The following functionality is new with v0.3b
  • Chado Installer
  • OBO, GFF, GAF and FASTA file loaders
  • Formalized API for customizing templates and future module development
  • Integration with Drupal Panels and Views to allow for non-programmatic
    customizations and data mining
• Currently under development
  • Chado bulk loader for loading of any tab delimited data
  • Additional support for chado tables, such as the Natural Diversity tables,
    publications, contact, etc.
GBrowse2

• Very widely installed genome browser
  (hundreds of installed instances)

• Perl/Apache based

• Support for multiple database backends
New in GBrowse2
                        (Since last BOSC)
• User accounts:

  • OpenID

  • Plugable authentication support (with example LDAP plugin)

• "Details multiplier" for smooth side scrolling

• iPad support

• Debian package

• REST API

• User defined "favorite tracks"
GMOD on the Cloud
• Still in its infancy

• Goal: really easy set up of servers for "naive"
  and/or time crunched users

• Platform: AWS

• Micro AMI to allow new users to experiment
  without spending much (any) money (my first
  month's bill: $0.65)
GMOD on the Cloud

• Available now: GBrowse2

 • Coming soon: mountable stores with
   standard datasets (code in git now)

• Also coming soon: AMI with Chado,
  GBrowse2, Tripal
More GMOD Resources
• Community meeting: October 12-13 in Toronto,
  Canada.

• Web page: http://gmod.org/

• Many mailing lists; help@gmod.org

• Workshops:

  • PAG, January, San Diego, California, 1day

  • NESCent, Summer '12, Durham, NC, 5 days
Acknowledgments
NatDiv                  Tripal                   GBrowse2
  Dave Clements          Stephen Ficklin           Lincoln Stein
  Scott Cain             Meg Staton                Chris Vandevelde
  Sook Jung              Chun-Huai Cheng           Sonu Lall
  Dorrie Main            Laceyanne Sanderson       Tony deCatanzaro
  Stephen Ficklin        Dorrie Main               Robert Buels
  Bob MacCallum                                    Peter Ruzanov
  Seth Redmond
  Naama Menda             Funding
  Rob Buels                  GMOD is supported by a specific
  Genevieve DeClerk          cooperative agreement from the USDA
                             Agricultural Research Service, and by NIH
  Maren Friesen              grants co-funded from the National
  Yuri Bendana               Human Genome Research Institute and
  Pantelis Topalis           the National Institute of General
                             Medical Sciences. Additionally, GBrowse
  Emmanuel Dialynas          development is supported by the Ontario
                             Ministry of Research and Innovation.

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G07-Misc-Gmod

  • 1. Project Update BOSC 2011 Scott Cain GMOD Project Coordinator Ontario Institute for Cancer Research scott@scottcain.net
  • 2. What Is GMOD? • A set of interoperable open-source software components for  visualizing, annotating, and managing biological data. • An active  community of developers and users asking diverse questions, and facing common challenges, with their biological data.
  • 4. What's New • Chado Natural Diversity Module • Tripal • GBrowse2 • GMOD in the Cloud
  • 7. Use case: insecticide resistance assay
  • 8. Use case: mosquito field collection
  • 9. Use case: rice growth condition
  • 10. Tripal: a construction toolkit for online biological databases Relational Database Web Content Management • Drupal GMOD Chado • Requires little or no programming Community supported • Users can change content directly Well documented • Well documented and supported Integrates with a suite of tools • Very Popular
  • 11. Tripal: a construction toolkit for online biological databases • Benefits – Reduced IT costs (less programming) – Faster time to release – Active development (released v0.3b in June) – Support: Mailing list, online tutorials, responsive developers – Already used by multiple genome databases – Use of Chado allows for use of other GMOD tools • Maker: automatic genome curation • Apollo: manual curation • GBrowse: genome visualization – Use of Drupal allows for incorporation of non-biological content • Forums, RSS feeds, community pages, • Site stake-holders can add / update content without waiting on programmers
  • 12. Tripal: a construction toolkit for online biological databases
  • 13. Tripal: what’s new? • The following functionality is new with v0.3b • Chado Installer • OBO, GFF, GAF and FASTA file loaders • Formalized API for customizing templates and future module development • Integration with Drupal Panels and Views to allow for non-programmatic customizations and data mining • Currently under development • Chado bulk loader for loading of any tab delimited data • Additional support for chado tables, such as the Natural Diversity tables, publications, contact, etc.
  • 14. GBrowse2 • Very widely installed genome browser (hundreds of installed instances) • Perl/Apache based • Support for multiple database backends
  • 15. New in GBrowse2 (Since last BOSC) • User accounts: • OpenID • Plugable authentication support (with example LDAP plugin) • "Details multiplier" for smooth side scrolling • iPad support • Debian package • REST API • User defined "favorite tracks"
  • 16. GMOD on the Cloud • Still in its infancy • Goal: really easy set up of servers for "naive" and/or time crunched users • Platform: AWS • Micro AMI to allow new users to experiment without spending much (any) money (my first month's bill: $0.65)
  • 17. GMOD on the Cloud • Available now: GBrowse2 • Coming soon: mountable stores with standard datasets (code in git now) • Also coming soon: AMI with Chado, GBrowse2, Tripal
  • 18. More GMOD Resources • Community meeting: October 12-13 in Toronto, Canada. • Web page: http://gmod.org/ • Many mailing lists; help@gmod.org • Workshops: • PAG, January, San Diego, California, 1day • NESCent, Summer '12, Durham, NC, 5 days
  • 19. Acknowledgments NatDiv Tripal GBrowse2 Dave Clements Stephen Ficklin Lincoln Stein Scott Cain Meg Staton Chris Vandevelde Sook Jung Chun-Huai Cheng Sonu Lall Dorrie Main Laceyanne Sanderson Tony deCatanzaro Stephen Ficklin Dorrie Main Robert Buels Bob MacCallum Peter Ruzanov Seth Redmond Naama Menda Funding Rob Buels GMOD is supported by a specific Genevieve DeClerk cooperative agreement from the USDA Agricultural Research Service, and by NIH Maren Friesen grants co-funded from the National Yuri Bendana Human Genome Research Institute and Pantelis Topalis the National Institute of General Medical Sciences. Additionally, GBrowse Emmanuel Dialynas development is supported by the Ontario Ministry of Research and Innovation.