Maintaining records of experimental data
- 1. Maintaining records of experimental data Presented by: Samiksha Sawant M.Pharm(IP), 3rd Sem
- 2. Data recording and retention • Data means recorded information, regardless of the form or the media in which it may be recorded • The retention of accurately recorded and retrievable research data is important for the progress of scientific integrity • The record should be sufficient detail to permit to permit: Examination for the purpose of replicating the research Responding to questions that may result from unintentional error/misinterpretation Establishing authenticity of the records Confirming validity of the conclusions Permit the filing of patent applications
- 3. Laboratory notebook • The experimental notebook is the most common medium for the documentation of experiments • A specific type notebook with prenumbered pages and places for date and investigator's and supervisor's signatures on each page • The first page of the book should include information about the investigator followed by table of content on the next pages • The book should include detailed information about of the equipments and materials used, sources of material, experimental methodology, time and conditions of the work, results and conclusions • Entries should be made in the notebook in permanent black ink and should be as legible and complete as possible. Do not use abbreviations, code names or product codes without defining them clearly • Draw a line through all errors. Do not erase
- 4. • Entries should always be made in the notebook without skipping pages or leaving empty spaces at the bottom of a page. If you wish to start an entry on a new page, draw a line through any unused portion of the previous page. • Never tear out or remove a page from the notebook. • Each page should be signed with the inventor's full name and dated. No entry should be changed or added to after signature. If the inventor has any additional information or corrections, a new entry should be made. • Each page of the notebook should be witnessed, signed and dated by a colleague who understands the inventor's work. • When the laboratory notebook is completely filled and is no longer required for reference, it should be indexed and stored in a safe location and, thereafter, handled in accordance with the company's established record retention and destruction policy for such documents.
- 5. Electronic lab notebooks • Electronic lab notebooks are a fairly new technology and offer many benefits to the user as well as organizations. • An electronic lab notebook (also known as electronic laboratory notebook, or ELN) is a computer program designed to replace paper laboratory notebooks • Electronic lab notebooks are easier to search upon, simplify data copying and backups, support collaboration amongst many users • ELNs can be divided into two categories: "Specific ELNs" contain features designed to work with specific applications, scientific instrumentation or data types. "Cross-disciplinary ELNs" or "Generic ELNs" are designed to support access to all data and information that needs to be recorded in a lab notebook.
- 6. Features of electronic lab note books • Labfolder is an electronic lab notebook that helps to document, organize and share your research data. • Digital Recording: All that is necessary to record your experiments can be combined in ELN text, tables, images, files. Simply drag and drop data elements where you want them to be. • Search and filter: Find what you're looking for in your notebook by filtering your research notes by project, author, tags and dates.
- 7. • ELNs store information online: Electronic lab notebooks facilitate structured online storage of information. Online storage provides security of information, as electronic lab notebooks require a password for entry. • Import data: Import Word, Excel and PDFs easily. Drag and drop them into ELN, where you can preview and extract the contents. Your Word files are separated into text, image and table elements in ELN.
- 8. • Organize your research: With ELN it's easy to organize your research using projects and folders. A powerful search engine helps to find all your documents. Template functions enable you to create protocols that can easily be shared with collaborators. • Collaborate with colleagues: ELN allows you to work on group projects with your colleagues. You can work together on projects, share templates, exchange, comment and re-use information.
- 9. • Protocol Templates: Re-use information and protocols: ELN allows you to create templates from your lab notebook and to share knowledge with your colleagues. • Image Annotation: You can use the most important features for image annotation right in ELN: Mark, circle, box, annotate and freehand label your images and photographs in an easy-to-use editor. • Full Audit Trail & Signatures: Any changes made to an entry are recorded, stored, timestamped and accessible in a version history (full audit trail). Digital signatures ensure the intellectual property of your research group.
- 10. • Team Communication: Send messages to all team members and create and assign tasks - so everyone knows what's going on and what has to be done. • Cloud and installable server solution: Redundant storage and daily backups keep your data safe. One can always start using the cloud version - if you decide for the server option later, the transfer of your data to your local servers is included when you buy the server version
- 11. • ELNs improve accuracy and precision of research: A common complaint, particularly in academic laboratories, is the difficulty individuals in a lab have interpreting information in other lab members’ paper lab notebooks. Electronic lab notebooks avoid issues associated with illegible handwriting and crossed-out entries. • ELNs are cost effective: As ELNs have increased in popularity, particularly in the pharmaceutical company, more vendors have produced this type of notebook, which has driven down prices. In addition, the amount of time saved by using an electronic lab notebook over a paper lab notebook contributes to its cost effectiveness.
- 12. Conclusion ELN has a number of advantages over that of paper lab book Though paper lab book are widely used today, ELN has promising features to emerge as the ideal recording tool of results in the near future!
- 13. References • An article on Proper Maintenance of a Laboratory Notebook(https://www.chem.tamu.edu/class/majors/syllabusm aterials/laboratorynotebook.htm) • Nine reasons to switch to electronic lab notebook by Labguru staff, Jan 2015, (http://blog.labguru.com/blog-labguru/10- reasons-to-ditch-paper-and-switch-to-electronic-lab-notbooks) visited on 22/10/15 • A Review of Electronic Laboratory Notebooks Available in the Market Today Michael Rubacha, Anil K. Rattan,* and Stephen C. Hosselet, Journal of Laboratory Automation 16: 90, feb 2011 • Guidelines for Keeping a Laboratory Record Dr. David R. Caprette (http://abacus.bates.edu/~ganderso/biology/resources/Lab_not ebook_guidelines_DR_Caprette.pdf) • An electronic lab notebook for laboratory research(https://www.labfolder.com/), visited on 22/10/15
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