This document provides guidance on assessing users who have difficulties using a mouse and provides potential solutions or alternative devices to investigate. It lists common mouse issues such as not being able to accurately move the pointer, hit buttons, double click fast enough, see the pointer, or move the pointer across the full screen. For each issue it suggests seating adjustments, software settings changes, or alternative devices like trackballs, touchpads, or switch devices to allow mouse functionality. It also lists alternatives for users who cannot hold or move a mouse but may have other abilities like keyboard, finger, head or switch control.