The document discusses the application of signed LMS (Least Mean Squares) based adaptive filtering techniques for noise cancellation in ECG signals, aimed at improving biotelemetry. Various filter structures are proposed to eliminate different noise types, such as 60Hz power line interference and baseline wander, with simulation results showing that the signed regressor LMS algorithm outperforms traditional LMS in terms of noise reduction while being computationally efficient. The study validates the effectiveness of these algorithms using real ECG signals from the MIT-BIH database, highlighting their potential for medical applications.