The document presents Ontocom, a framework for estimating development efforts for large-scale business ontologies. Ontocom consists of a process for effort estimation, a formula and tool for calculating estimations, and a methodology for customizing the estimations to a particular company. It estimates ontology development costs with 30% accuracy in 80% of cases. The framework was successfully applied in an ontology project at a large German telecommunications operator as part of a service-oriented architecture initiative.