Python was created in 1980 by Guido Van Rossum. There are differences between Python versions 2.x and 3.x related to compatibility, understandability, maturity, and robustness. Some frameworks like Twisted and gevent have not yet migrated to Python 3.x, while others like NumPy, Django, Flask, CherryPy, Pyramid, PIL, cx_Freeze, and Py2exe have migrated. The document also includes code examples and information about a Python developer.