There are three main types of anti-setoff powders used in printing: calcium carbonate, sugar-based, and starch-based. Calcium carbonate is heavy and low-dust but needs to be surface treated to avoid abrasion. Sugar-based powder dissolves easily but cannot be used with dryers. Starch powder has spherical grains, flows well, and is gentle on machines. The key is selecting the right powder for the job and application method to minimize powder usage.