Differentiated instruction is an approach to teaching that aims to meet the needs of diverse learners by providing multiple paths to learning. Teachers can differentiate the content, process, and products based on students' readiness levels, interests, and learning profiles. Key strategies for differentiation include tiered instruction, anchoring activities, flexible grouping, and compacting the curriculum. While differentiation aims to be fair to students, it is not about giving all students the same instruction or having many different lesson plans - it is about creating an instructional approach that best meets the needs of each learner.