This document discusses methods for differentiating instruction for higher-level learners. It defines differentiation as responding to learners' needs and outlines several key principles, including focusing on essentials, respecting student differences, and modifying content, process and products. The document provides strategies for differentiating content, process and products, and assessing student readiness, interests and learning styles to better target instruction. A variety of specific differentiation strategies are presented, such as tiered activities, learning centers, compacting content, independent projects and mentorships.