This document discusses regression inference and significance testing for the slope parameter in a simple linear regression model. It provides details on conducting a t-test for the slope of the population regression line to test if the slope is equal to some hypothesized value (the null hypothesis) versus an alternative hypothesis where the slope is greater than, less than, or not equal to the hypothesized value. Examples are given on interpreting test statistics and p-values and drawing conclusions about the evidence for or against a linear relationship between two variables based on the regression analysis and test results.