Microfluidics involves manipulating small amounts of fluids using channels tens to hundreds of micrometers in size, allowing for controlled mixing, efficient mass transport, and single cell manipulation. Lithography is used to fabricate microfluidic devices by transferring geometric patterns from a photo mask to a light-sensitive resist on a substrate through a process involving film deposition, exposure, development, and etching. The miniaturization benefits of microfluidics include decreased reagent consumption, rapid heat transfer, fast diffusive mixing, and automation/integration.