This paper analyzes the impact of different refrigerants (R12, R134a, and R600a) on compressor work in domestic refrigerators. The findings show that R134a has the lowest compressor work and is the most environmentally friendly option due to its zero ozone depletion potential, whereas R600a is a viable alternative but less efficient. The study highlights the importance of using eco-friendly refrigerants to mitigate global warming and ozone layer depletion.