This document discusses problem-based learning (PBL), an instructional approach where students learn through facilitated problem solving. PBL is student-centered and sees the instructor as a facilitator. It has benefits like enhancing critical thinking but disadvantages like requiring more time and resources. The document provides examples of PBL used in medical school, K-12, and undergraduate science courses. It reflects on incorporating PBL into a molecular biology laboratory through an authentic genomics research project.