This study investigates the impact of first-language (L1) interference on second-language (L2) learning among Ghanaian Fante speakers learning English. Utilizing thematic analysis with 20 junior high school students, the findings reveal that factors like confidence and lexical knowledge significantly affect second language acquisition, highlighting the challenges posed by L1 interference. The study offers insights for educators and policymakers to better understand the complexities of second language learning in Ghana.