The document contains notes from a Calculus I class at New York University on December 13, 2010. It discusses using the substitution method for indefinite and definite integrals. Examples are provided to demonstrate how to use substitutions to evaluate integrals involving trigonometric, exponential, and polynomial functions. The key steps are to make a substitution for the variable in terms of a new variable, determine the differential of the substitution, and substitute into the integral to transform it into an integral involving only the new variable.