OXYGEN CASCADE, HYPOXIA AND ODC copy.ppt
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The document discusses the importance of oxygen for aerobic respiration and details the oxygen cascade from air to cellular utilization. It explains the physiological mechanisms of oxygen transport and the saturation of hemoglobin with oxygen. It also introduces types of hypoxia and the concept of oxygen flux from the left ventricle.
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OXYGEN CASCADE, HYPOXIA AND ODC copy.ppt
- 1. OXYGEN CASCADE, HYPOXIA AND ODC - DR. SRAVANI -MODERATOR DR P RAJESHWAR SIR
- 2. INTRODUCTION • Oxygen is vital for life sustaining aerobic respiration, which basically occurs in cellular mitochondria • Normal oxygen content in mitochondria is 10mmhg. • At a point below 1-2 mmhg, ( pasteur point) anerobic respiration sets in.
- 3. OXYGEN CASCADE • O2 at air ( sea level) is 160 mmhg • At mitochondria is 10 mmhg • The o2 transport down this gradient in oxygen cascade
- 4. STEPS • UPTAKE BY LUNGS • TRANSPORT IN BLOOD • GLOBAL DELIVERY TO TISSUES • REGIONAL DISTRIBUTION OF O2 DELIVERY • DIFFUSION FROM CAPILLARY TO CELL • CELLULAR UTILIZATION OF O2
- 11. • In Combined (97%) form 1 gm Hb carries 1.31 ml of o2 • Dissolved form(2-3%), obeys henrys law, 100ml plasma carries 0.3ml of o2 • When FiO2 increased to 100% small amount of o2 dissolves in plasma at a rate of 0.3 ml/100 ml plasma • But theres no significant increase in amount of o2 carried by hemoglobin as its already 95% saturated with oxygen
- 28. Oxygen flux The amount of oxygen which leaves left ventricle per minute. DO2 DO2= O2 Bound to Hb+ dissolved O2