Partial derivatives are used to calculate the rate of change of a function of two or more variables with respect to one variable, while holding the other variables constant. The partial derivative of z with respect to x, denoted ∂z/∂x, is defined as the limit of the difference quotient as Δx approaches 0, while holding y constant. Similarly, the partial derivative of z with respect to y, denoted ∂z/∂y, is defined as the limit of the difference quotient as Δy approaches 0, while holding x constant. Notations for higher order partial derivatives are also introduced. An example problem finds the first and second order partial derivatives of the function z=x^2y^3+6