This document discusses synchronization issues that can arise in designs with multiple clock domains and presents techniques for reliably handling clock domain crossings. It describes how metastability can occur during data transfers between clock domains and impact reliability. Advanced synchronization techniques using synchronization IP blocks and EDA tools are recommended to automatically handle clock domain crossings in a correct-by-design manner and verify the design is sign off-ready. Synchronization is a critical part of most modern chip designs that must be carefully analyzed and validated.