Newton contributed to a major paradigm shift in science through his synthesis of the works of prior scientists like Galileo, Bacon, and Descartes. In his seminal work Principia, Newton laid out a system of classical mechanics through his three laws of motion and universal law of gravitation. This provided a mathematical framework that could quantitatively explain and predict many physical phenomena, representing something truly new and revolutionary in science. While building on prior work, Newton's act of creative synthesis was highly influential in establishing new mechanistic and empirical approaches that came to define the scientific revolution and modern science.