The document discusses challenges in system-on-chip design. The main challenges are:
1. Increasing design productivity by over 100% per technology node to keep up with Moore's Law scaling.
2. Managing power, especially for low-power, wireless, and multimedia applications.
3. Integrating heterogeneous technologies like MEMS and optoelectronics at the system level.
4. Developing test methodologies for system-on-chips, including reusable tests and built-in self-test for analog and digital components.